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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90AB4P
All Species:
44.55
Human Site:
Y249
Identified Species:
89.09
UniProt:
Q58FF6
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q58FF6
NP_031381
505
58264
Y249
T
K
K
I
K
E
K
Y
T
D
R
E
E
L
N
Chimpanzee
Pan troglodytes
A5A6K9
733
84754
Y285
K
K
K
I
K
E
K
Y
I
D
Q
E
E
L
N
Rhesus Macaque
Macaca mulatta
XP_001098426
696
80269
Y276
T
K
K
I
K
E
K
Y
I
D
Q
E
E
L
N
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P11499
724
83307
Y276
T
K
K
I
K
E
K
Y
I
D
Q
E
E
L
N
Rat
Rattus norvegicus
P34058
724
83263
Y276
T
K
K
I
K
E
K
Y
I
D
Q
E
E
L
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518700
789
90657
Y368
T
K
K
I
K
E
K
Y
I
D
Q
E
E
L
N
Chicken
Gallus gallus
Q04619
725
83409
Y277
T
K
K
I
K
E
K
Y
I
D
Q
E
E
L
N
Frog
Xenopus laevis
NP_001086624
722
82939
Y274
T
K
K
I
K
E
K
Y
I
D
Q
E
E
L
N
Zebra Danio
Brachydanio rerio
O57521
725
83339
Y275
K
K
K
I
K
E
K
Y
I
D
Q
E
E
L
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
Y269
K
K
T
I
K
E
K
Y
T
E
D
E
E
L
N
Honey Bee
Apis mellifera
XP_395168
718
82735
Y272
K
K
T
I
K
E
K
Y
T
E
D
E
E
L
N
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
Y255
T
K
K
I
K
E
K
Y
F
E
D
E
E
L
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
49.9
59.3
N.A.
N.A.
56.7
57
N.A.
50.9
54.9
53.7
52.5
N.A.
46.7
47.9
46.4
N.A.
Protein Similarity:
100
59
64.8
N.A.
N.A.
62.2
62.4
N.A.
56.6
61.9
61.3
61.3
N.A.
57.1
57.5
57.2
N.A.
P-Site Identity:
100
80
86.6
N.A.
N.A.
86.6
86.6
N.A.
86.6
86.6
86.6
80
N.A.
73.3
73.3
80
N.A.
P-Site Similarity:
100
86.6
93.3
N.A.
N.A.
93.3
93.3
N.A.
93.3
93.3
93.3
86.6
N.A.
80
80
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
75
25
0
0
0
0
% D
% Glu:
0
0
0
0
0
100
0
0
0
25
0
100
100
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
100
0
0
0
0
67
0
0
0
0
0
0
% I
% Lys:
34
100
84
0
100
0
100
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
100
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
100
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
67
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
67
0
17
0
0
0
0
0
25
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _